Ai Kayano: 10 Best Anime Girls She Brought to Life

If there’s one thing Ai Kayano knows how to do, it’s heal our souls with her unforgettable anime roles!

Believe it or not, before becoming the voice behind some of your favorite characters, Kayano originally dreamt of a career in the beauty industry.

In fact, she even started courses at a vocational school because she wanted to “heal people” in a more traditional way. But after witnessing the magic of Aria, Kayano swapped face masks for microphones and pursued acting, all while still paying her way through school.

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She got her break with the 2010 OVA Princess Resurrection, and if you squint during A Certain Magical Index II, you might catch her sneaking into the background as Itsuwa.

From humble beginnings to iconic anime girls, let’s dive into the top characters voiced by this multi-talented actress!

1. Menma (Anohana)

Menma (Anohana) anime best girl

Ai Kayano voiced Meiko Honma or Menma in Anohana: The Flower We Saw That Day. For awarding as Menma, she received the Best Newcomer Award at the 6th Voice Voice Awards in 2012.

Additionally, with Haruka Tomatsu and Saori Hayami, Kayanon performed the series’ ending theme “Secret Base – Kimi ga Kureta Mono (10 years after Ver.)”, a cover of the song featuring the band Zone.

2. Inori Yuzuriha (Crown of Guilty)

Inori Yuzuriha (Guilty Crown) anime mecha best girl

Ai Kayano plays the main heroine Inori Yuzuriha in the mecha romance anime Guilty Crown.

Inori first appears emotionless and only cares about following Gai’s orders. After meeting and living with Shu, Inori gradually becomes more emotional, smiles more and even shows embarrassment when she gets too close to Shu.

3. Mashiro Shiina (Sakurasou’s Pet Girl)

Mashiro Shiina (The Pet Girl of Sakurasou) anime best waifu

Mashiro Shiina is the main protagonist of Sakurasou no Pet no Kanojo or The Pet Girl of Sakurasou.

This waifu starring Ai Kayano lives in Room 202 of Sakura Dormitory. Mashiro is a world-renowned artist who transferred to Suiko as a sophomore to study drawing. He aims to draw manga.

Apart from drawing, he greatly admires other people. As a result, Sorata Kanda is forced to constantly take care of Mashiro, to the point that he has to practically dress her up, or she will go to school naked.

4. Shiro (No Game No Life)

Shiro (No Game No Life) anime white hair girl

Shiro is one of the main protagonists of the anime No Game No Life, alongside Sora, played by Matsuoka Yoshitsugu.

Abandoned by his parents, Shiro is an 11-year-old gamer, along with his half-brother, Sora, making group (Blank/Kuhaku).

5. Akari Kawamoto (3-gatsu no Lion)

Akari Kawamoto (3-gatsu no Lion) anime shaft studio

Akari Kawamoto is one of the main characters in the family anime series March Comes in Like a Lion.

Akari is the head of the family of Kawamoto’s sister. She took care of her two younger sisters after their father ran away and their mother and grandmother died.

Akari meets Rei Kiriyama and takes her to a place she’s never brought back home the first time. Finding Rei drunk, Akari takes him and that’s when Akari and the rest of the circle officially become acquainted with Rei.

6. Darkness (KonoSuba)

Darkness (KonoSuba)

Dustiness Ford Lalatina, commonly known as Darkness, is one of the three main female protagonists of the KonoSuba series.

Darkness is a crusader with masochistic tendencies who joins Kazuma’s party.

7. Mamako Oosuki (Okaasan Online)

Oosuki Mamako (Okaasan Online) anime hot mom milf

Mamako Oosuki from Do You Love Your Mom and Her Two-Punch Multi-Target Attack? or Okaasan Online is one of the hot mama characters in the anime.

Mamako is a kind, loving, and motherly woman. Due to his gentle nature, he is sometimes very easy going often very kind to strangers, even when they are dealing with him.

8. Utaha Kasumigaoka (Saekano)

Utaha Kasumigaoka (Saekano) anime best girl waifu

Kayanon is back in pairs with Tsugutsugu in the series Saenai Heroine no Sodatekata or Saekano: How to Raise a Boring Girlfriend.

Utaha Kasumigaoka is one of the main characters of this series. He is a young up-and-coming novelist and a student in class 3C who has a secret identity as a writer.

9. Alice Zuberg (Sword Arts Online: Alicization)

Alice Zuberg (Sword Art Online: Alicization) anime best girl waifu

Alice Zuberg is one of the main characters in the Alicization Arc in the Sword Art Online series.

Alice is Eugeo and Kirito’s childhood friend.

For accidentally breaking the Taboo Index in her childhood, Alice is captured and taken to the Central Cathedral, where she is forced to become an integrity knight, under the name Alice Synthesis Thirty.

10. Dominique de Sade (Vanitas no Carte)

Dominique de Sade (Vanitas no Carte)

Dominique de Sade, nicknamed Domi, is one of the main characters of The Case Study of Vanitas.

A Vampire from the Red Moon, he is a childhood friend of Noé Archiviste, having met him thanks to his grandfather.

Born the youngest of the influential de Sade family, Dominique adopted a brash and dignified personality, establishing himself as Noé’s “protector”.


Ai Kayano has certainly made her mark. Whether she’s voicing sweet, strong, or complex characters, she always brings them to life in a way that touches our hearts.

With so many memorable roles under her belt, it’s clear that Kayano’s career will continue to thrive—and we can’t wait to see (and hear) what she does next!

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